New papers in 2024
Liu A, Kage F, Abdulkareem AF, Aguirre-Huamani MP, Sapp G, Aydin H, Higgs HN (2024) Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51. Nat. Cell Biol. PMID: 38594588
Liu A, Hatch AL, Higgs HN (2024) Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin. Mol. Biol. Cell PMID: 38019609
Select Publications:
Fung TS, Chakrabarti R, Higgs HN (2023) The multiple links between actin and mitochondria. Nat. Rev. Mol. Cell Biol. PMID: 37277471.
Harned TC, Stan RV, Cao Z, Chakrabarti R, Higgs HN, Chang CCY, Chang TY (2023) Acute ACAT1/SOAT1 blockade increases MAM cholesterol and strengthens ER-mitochondria connectivity. Int. J. Mol. Sci. PMID: 36982602
Kage F, Vicente-Manzanares M, McEwan BC, Kettenbach AN, Higgs HN (2022) Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division. Mol. Biol. Cell. PMID: 35427150.
Fung TS, Chakrabarti R, Kollasser J, Rottner K, Stradal TEB, Kage F, Higgs HN (2022) Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria. Current Biology. PMID: 35290799.
Chakrabarti R, Fung TS, Kang T, Elonkirjo PW, Suomalainen A, Usherwood EJ, Higgs HN (2022) Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation. J Cell Bio. PMID: 36102863.
Liu A, Kage F, Higgs HN (2021) Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division. Mol. Biol. Cell. PMID: 34347505.
Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN (2020). Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner. Mol Biol Cell. PMID: 32267199.
A M, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN (2020). Regulation of INF2-mediated actin polymerization through the site-specific lysine acetylation of actin itself. Proc Natl Acad Sci USA. PMID: 31871199.
Fung TS, Ji WK, Higgs HN, Chakrabarti R (2019). Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors. J Cell Sci. PMID: 31413070.
A M, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN (2019). A complex containing lyseine-acetylated actin inhibits the formin INF2. Nat Cell Biol. PMID: 30962575
Young LE, Higgs HN (2018). Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units. Curr Bio. PMID: 29910076.
Young, L. E., Latario, C. J., & Higgs, H. N. (2018). Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly. J Cell Sci, 131(21), jcs220814.
Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN. (2018) INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. JCB. PMID: 29142021
Ji WK, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs HN (2017). Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. JCB. PMID: 29158231.
Hatch, A. L., Ji, W. K., Merrill, R. A., Strack, S. & Higgs, H. N. (2016). Actin filaments as dynamic reservoirs for Drp1 recruitment. Mol Biol Cell. 27(20):3109-3121.
Ji, W. K., Hatch, A. L., Merrill, R. A., Strack, S. & Higgs, H. N. (2015) Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. eLife. PMID: 26609810.
Young, L. E., Heimsath, E. G. & Higgs, H. N. (2015) Cell type-dependent mechanisms for formin-mediated assembly of filopodia. Mol. Biol. Cell. 26(25): 4646-4659.
Gurel, P. S., Guo, B., Shu, R., Mirke, D. F. & Higgs, H. N. (2015) Assembly and turnover of short actin filaments by the formin INF2 and profilin. J. Biol. Chem. 11:290(37): 22494-22506.
Gauvin, T. J., Young, L. E. & Higgs, H. N. (2015) The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. Mol. Biol. Cell. 26(3): 467-77.